Albumin and globulin are the two major proteins found in the blood. Albumin is produced in the liver and is important for transporting many molecules in the blood and making sure that the blood does not leak into the tissues of the body. Globulin is produced in the liver and by the immune system. Globulin helps fight infection and transports nutrients. There are three main groups of globulins called alpha, beta and gamma globulins. Some of the gamma globulins are immunoglobulins which are produced by the immune system. These are named lgM component, lgG component and lgA component.

The albumin/globulin ratio is, as its name says, the amount of albumin in the blood compared to the amount of globulin in the blood. The albumin value is divided by the globulin value to get the ratio. The ratio is primarily used to evaluate liver function but also is an indicator of many other possible problems.

NORMAL LEVELS

The albumin/globulin ratio normal levels are from 0.8 to 2.0.

LOWER THAN NORMAL LEVELS

Lower than normal levels of the albumin/globulin ratio may indicate:

Malignant tumor in bone marrow

Autoimmune diseases (where the body starts attacking its own organs)

Cirrhosis of the liver (Inflammation and scar tissue in the liver)

Kidney disease


HIGHER THAN NORMAL LEVELS

Higher than normal levels of the albumin/globulin ratio may indicate:
Leukemia (Disease affecting white blood cells)
Liver problems
Hypothyroidism (Low thyroid activity)

Too high protein diet

Diseases like AIDS

Kidney disease

Intestinal disease