There is another type of antidepressant known as atypical (not typical) antidepressants. The most commonly prescribed of this class of drugs is bupropion (Wellbutrin). It acts as a reuptake inhibitor for norepinephrine and dopamine. It is also believed to act as an antagonist for nicotine receptors. In 2007, there were over 20 million prescriptions for Wellbutrin, making it the fourth most prescribed antidepressant.

In many people, the use of bupropion is found to increase the risk of seizures. This was why bupropion was withdrawn from the U.S. market in 1986. When it was determined that the seizure risk was reduced by lowering the dosage of the drug, bupropion was reintroduced in 1989. Since the risk of seizures is not more than for other antidepressants, the FDA allowed it to be sold again.

One reason for its use is that it is thought to not cause sexual dysfunction as much as other antidepressants.
•    Some of the side effects of bupropion are:
•    Dry mouth
•    Nausea
•    Insomnia
•    Tremor
•    Excessive Sweating
•    Tinnitus (ringing in the ears)
•    Skin rashes