There is another type of antidepressant called a selective serotonin reuptake enhancer (“SSRE”).  SSREs do the opposite of the selective serotonin reuptake inhibitors (SSRIs).  Both drugs seek to affect the amount of serotonin in the brain.

The SSRIs seek to increase the amount of serotonin in the brain by reducing the rate that the serotonin is absorbed back into the cells releasing it.  SSREs do the opposite by reducing the amount of the serotonin in the brain by increasing the rate that serotonin is absorbed.

Like SSRIs, the exact way that SSREs work is not known or understood.

Tianeptine is only one drug of this type that is marketed under the names Stablon, Coaxil and Tatinol.


The side effects of this SSRE are:
•    Abdominal pain
•    Constipation
•    Dry mouth
•    Loss of appetite
•    Vomiting
•    Flatulence
•    Insomnia
•    Drowsiness
•    Dizziness
•    Muscle aches
•    Headache
•    Nausea