Although the precise mechanism of action isn’t clear, serotonin and norepinephrine reuptake inhibitors (SNRIs) are drugs that inhibit the reuptake of these two neurotransmitters, and by doing this increase the amount of both neurotransmitters in the brain.  It has also been speculated that these drugs may be slowing the reuptake of dopamine and this may increase the feelings of pleasure.

The following are the bestselling SNRIs:

Generic Name

Duloxetine
Venlafaxine
Mirtazapine
Nefazodone

Trade Name

Cymbalta®
Effexor® Effexor XR®
Remeron®
Serzone®

SEROTONIN NOREPINEPHRINE REUPTAKE INHIBITORS SIDE EFFECTS

All SNRIs have the same general mechanism of action and side effects. However, individual SNRIs have some different pharmacological characteristics. That means you may respond differently to certain SNRIs or experience different side effects with different SNRIs. For instance, you may have unpleasant side effects with one SNRI but not another.

Side effects of SNRIs include:
•    Nausea
•    Vomiting
•    Dizziness
•    Insomnia
•    Sleepiness
•    Trouble sleeping
•    Abnormal dreams
•    Constipation
•    Sweating
•    Dry mouth
•    Yawning
•    Tremors
•    Gas
•    Anxiety
•    Agitation
•    Abnormal vision, such as blurred vision or double vision
•    Headache
•    Sexual dysfunction